154 research outputs found
The impact of business process outsourcing on firm performance and the influence of governance : a long term study in the German banking industry
Does BPO pay off at the firm-level? Although there are several studies which analyze the potential benefits of BPO, there is a virtual absence of research papers on BPO outcomes. Based on an analysis of 137 Business process outsourcing (BPO) ventures at 254 German banks in a period between 1994 and 2005, we found that the outsourcer's financial performance in terms of profitability and cost efficiency was increased significantly compared to industry peers without BPO. The increase stems not from workforce reductions but rather from increased employee productivity. Further, we show how BPO governance ensures BPO success: individually negotiated outsourcing contracts help to improve cost efficiency and profitability measures. Relational governance based on trust has only positive effects on profitability. Keywords: Business Process Outsourcing, firm performance, firm characteristics, banking, German banks, governance JEL Classifications: G21, L14, L21, L2
Self-talk and emotions in tennis players during competitive matches
A theory-driven classification recently introduced to sport psychology
distinguishes between goal-directed self-talk as a controlled type of
self-talk, and spontaneous self-talk as an uncontrolled type of selftalk.
Based on this classification, the aim of this study was to explore
the relationship between self-talk and emotions. To this end, twenty
competitive tennis matches were video-recorded. Shortly after the
match, the players were confronted with situations from the match
and asked to rate the intensity of their emotions experienced, the
intensity of their outward emotional reactions, and to report on their
self-talk. Multilevel fixed and random effect models showed that the
intensity of emotions experienced and outward emotional reactions
were lower in instances where players reported solely goal-directed
self-talk than in instances where players reported solely spontaneous
self-talk. Moreover, in the fixed model, the intensity of emotions
experienced was also lower in instances where players reported
goal-directed self-talk in conjunction with spontaneous self-talk,
compared to instances where players reported solely spontaneous
self-talk. Finally, exploratory analyses suggest
that these effects are mostly true for negative emotions rather than
positive ones. Overall, the findings support the relevance of dualprocess
self-talk approaches. These findings encourage players to
gain awareness about their emotions through spontaneous self-talk,
while they can use goal-directed self-talk for emotion regulation.
Lay summary: During a match, most tennis players talk a lot to
themselves. This study shows that their self-talk is related to (a) the
emotions they experience and (b) the emotions they show to the
outside. Specifically, a goal-oriented type of self-talk is related to less
intense emotions.
IMPLICATIONS FOR PRACTICE
Players can gain awareness about their emotional states through
spontaneous self-talk.
Players can use goal-directed self-talk to proactively and reactively
regulate emotions. Video-assisted recall can be helpful to assess and learn to
deal with challenging psychological states during sport
competitions
Lifetime vs. rate capability: Understanding the role of FEC and VC in high-energy Li-ion batteries with nano-silicon anodes
Fluoroethylene carbonate (FEC) and vinylene carbonate (VC) are the most frequently used electrolyte components to enhance the lifetime of anode materials in Li-ion batteries, but for silicon it is still ambiguous when FEC or VC is more beneficial. Herein, a nanostructured silicon/carbon anode derived from low-cost HSiCl3 is tailored by the rational choice of the electrolyte component, to obtain an anode material outperforming current complex silicon structures. We demonstrate highly reversible areal capacities of up to 5 mA h/cm2 at 4.4 mg/cm2 mass loading, a specific capacity of 1280 mA h/gElectrode, a capacity retention of 81% after 500 deep-discharge cycles versus lithium metal and successful full-cell tests with high-voltage cathodes meeting the requirements for real application. Electrochemical impedance spectroscopy and post-mortem investigation provide new insights in tailoring the interfacial properties of silicon-based anodes for high performance anode materials based on an alloying mechanism with large volume changes. The role of fluorine in the FEC-derived interfacial layer is discussed in comparison with the VC-derived layer and possible degradation mechanisms are proposed. We believe that this study gives a valuable understanding and provides new strategies on the facile use of additives for highly reversible silicon anodes in Li-ion batteries.Fil: Jaumann, Tony. Ifw Dresden; AlemaniaFil: Balach, Juan Manuel. Ifw Dresden; AlemaniaFil: Langklotz, Ulrike. Technische Universität Dresden; AlemaniaFil: Sauchuk, Viktar. Fraunhofer Institute for Ceramic Materials and Systems; AlemaniaFil: Fritsch, Marco. Fraunhofer Institute for Ceramic Materials and Systems; AlemaniaFil: Michaelis, Alexander. Technische Universität Dresden; AlemaniaFil: Teltevskij, Valerij. Leibniz Institute for Solid State and Materials Research; AlemaniaFil: Mikhailova, Daria. Leibniz Institute for Solid State and Materials Research; AlemaniaFil: Oswald, Steffen. Leibniz Institute for Solid State and Materials Research; AlemaniaFil: Klose, Markus. Leibniz Institute for Solid State and Materials Research; Alemania. Technische Universität Dresden; AlemaniaFil: Stephani, Guenter. Branch Lab Dresden. Fraunhofer Institute for Manufacturing Technology and Advanced Materials; ArgentinaFil: Hauser, Ralf. Branch Lab Dresden. Fraunhofer Institute for Manufacturing Technology and Advanced Materials; ArgentinaFil: Eckert, Jürgen. Technische Universität Dresden; Alemania. Leibniz Institute for Solid State and Materials Research; AlemaniaFil: Giebeler, Lars. Leibniz Institute for Solid State and Materials Research; Alemania. Technische Universität Dresden; Alemani
Magnetic properties of small Pt-capped Fe, Co and Ni clusters: A density functional theory study
Theoretical studies on M (M = Fe, Co, Ni) and MPt (for
= 3, 4, 5, 20) clusters including the spin-orbit coupling are done using
density functional theory. The magnetic anisotropy energy (MAE) along with the
spin and orbital moments are calculated for M icosahedral clusters. The
angle-dependent energy differences are modelled using an extended classical
Heisenberg model with local anisotropies. From our studies, the MAE for
Jahn-Teller distorted Fe, Mackay distorted Fe and nearly
undistorted Co clusters are found to be 322, 60 and 5 eV/atom,
respectively, and are large relative to the corresponding bulk values, (which
are 1.4 and 1.3 eV/atom for bcc Fe and fcc Co, respectively.) However, for
Ni (which practically does not show relaxation tendencies), the
calculated value of MAE is found to be 0.64 eV/atom, which is
approximately four times smaller compared to the bulk fcc Ni (2.7
eV/atom). In addition, MAE of the capped cluster (FePt) is
enhanced compared to the uncapped Jahn-Teller distorted Fe cluster
Targeting ALK in Neuroendocrine Tumors of the Lung
Background
Anaplastic lymphoma kinase (ALK) rearrangements are known oncogenic drivers in non-small cell lung cancer (NSCLC). Few case reports described the occurrence of such rearrangements in large cell neuroendocrine carcinomas (LCNECs) of the lung without information on clinical responses to ALK tyrosine kinase inhibitors (TKIs) in these cases. Currently, neuroendocrine tumors of the lungs are not screened for ALK rearrangements.
Methods
To illustrate the clinical impact of molecular characterization in LCNECs, we report the disease course in three patients with ALK-rearranged metastatic LCNEC from our clinical routine, as well as their treatment response to ALK TKIs (index cases). To gain insight into the prevalence of ALK rearrangements in neuroendocrine tumors of the lung, we analyzed a retrospective cohort of 436 tumor biopsies including LCNEC (n = 61), small cell lung cancer (SCLC) (n = 206), typical (n = 91) and atypical (n = 69) carcinoids, and mixed histology (n = 9) for the presence of ALK rearrangements using a sequential diagnostic algorithm. ALK immunohistochemistry (IHC) was evaluable in 362 cases; fluorescence in situ hybridization (FISH) was evaluable in 28 out of the 35 IHC-positive cases, followed by next-generation sequencing (NGS) that was available in 12 cases.
Results
Within the retrospective cohort, ALK IHC was positive in 35 out of 362 (9.7%) evaluable samples. FISH was positive in 3 out of the 28 (10.7%) evaluable cases: 2 with atypical carcinoids and 1 with LCNEC. Additionally, the 3 index cases showed positive ALK IHC, which was confirmed by NGS. Within the retrospective cohort, NGS confirmed the presence of an ALK genomic rearrangement in one FISH-positive atypical carcinoid where material was sufficient for sequencing. Two out of three patients with metastatic ALK-rearranged LCNEC received up-front treatment with the ALK TKI alectinib and showed rapid tumor response at all metastatic sites, including multiple brain metastases.
Conclusions
ALK rearrangements represent rare but targetable oncogenic driver alterations in LCNEC. Contrarily to NSCLC, the detection of ALK rearrangements in neuroendocrine tumors of the lung is challenging, since ALK IHC can lead to false-positive results and therefore needs confirmation by FISH or NGS. Up-front comprehensive molecular profiling with NGS should be performed in metastatic LCNEC in order not to miss actionable genomic alterations
Targeting ALK in Neuroendocrine Tumors of the Lung.
Background
Anaplastic lymphoma kinase (ALK) rearrangements are known oncogenic drivers in non-small cell lung cancer (NSCLC). Few case reports described the occurrence of such rearrangements in large cell neuroendocrine carcinomas (LCNECs) of the lung without information on clinical responses to ALK tyrosine kinase inhibitors (TKIs) in these cases. Currently, neuroendocrine tumors of the lungs are not screened for ALK rearrangements.
Methods
To illustrate the clinical impact of molecular characterization in LCNECs, we report the disease course in three patients with ALK-rearranged metastatic LCNEC from our clinical routine, as well as their treatment response to ALK TKIs (index cases). To gain insight into the prevalence of ALK rearrangements in neuroendocrine tumors of the lung, we analyzed a retrospective cohort of 436 tumor biopsies including LCNEC (n = 61), small cell lung cancer (SCLC) (n = 206), typical (n = 91) and atypical (n = 69) carcinoids, and mixed histology (n = 9) for the presence of ALK rearrangements using a sequential diagnostic algorithm. ALK immunohistochemistry (IHC) was evaluable in 362 cases; fluorescence in situ hybridization (FISH) was evaluable in 28 out of the 35 IHC-positive cases, followed by next-generation sequencing (NGS) that was available in 12 cases.
Results
Within the retrospective cohort, ALK IHC was positive in 35 out of 362 (9.7%) evaluable samples. FISH was positive in 3 out of the 28 (10.7%) evaluable cases: 2 with atypical carcinoids and 1 with LCNEC. Additionally, the 3 index cases showed positive ALK IHC, which was confirmed by NGS. Within the retrospective cohort, NGS confirmed the presence of an ALK genomic rearrangement in one FISH-positive atypical carcinoid where material was sufficient for sequencing. Two out of three patients with metastatic ALK-rearranged LCNEC received up-front treatment with the ALK TKI alectinib and showed rapid tumor response at all metastatic sites, including multiple brain metastases.
Conclusions
ALK rearrangements represent rare but targetable oncogenic driver alterations in LCNEC. Contrarily to NSCLC, the detection of ALK rearrangements in neuroendocrine tumors of the lung is challenging, since ALK IHC can lead to false-positive results and therefore needs confirmation by FISH or NGS. Up-front comprehensive molecular profiling with NGS should be performed in metastatic LCNEC in order not to miss actionable genomic alterations
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